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Updated: May 23, 2026

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Presumptive steroid-responsive radiculoneuritis in dogs.

Carmen Manuela Stan1, Matthew James2, Mark Lowrie3

  • 1Department of Neurology and Neurosurgery Service, Pride Veterinary Referrals, IVC Evidensia, Derby DE24 8HX, United Kingdom.

Journal of Veterinary Internal Medicine
|May 21, 2026
PubMed
Summary

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Presumptive steroid-responsive radiculoneuritis (PSRRN) in dogs presents with spinal nerve enlargement and chronic monoparesis. MRI findings are suggestive but not definitive, emphasizing the need to consider inflammatory causes.

Area of Science:

  • Veterinary Neurology
  • Canine Medicine
  • Inflammatory Neuropathies

Background:

  • Presumptive steroid-responsive radiculoneuritis (PSRRN) in dogs is a rare condition that can mimic neoplasia due to similar clinical and imaging features.
  • Accurate differentiation is crucial for determining the appropriate prognosis and treatment plan for affected dogs.

Purpose of the Study:

  • To characterize the clinical presentation, diagnostic findings, MRI features, treatment strategies, and outcomes for dogs diagnosed with PSRRN affecting spinal nerves and nerve roots.
  • To improve the diagnostic accuracy and management of canine radiculoneuritis.

Main Methods:

  • A retrospective review was conducted on 15 dogs diagnosed with PSRRN at two UK referral centers between 2019 and 2025.
  • Inclusion criteria involved MRI findings consistent with nerve and nerve root inflammation in specific spinal cord segments (C6-T2 or L4-S3) and a minimum 12-month follow-up period.
Keywords:
German Shepherddogspresumptive immune-mediated neuropathypresumptive steroid-responsive radiculoneuritisspinal nerve and nerve roots

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Main Results:

  • Dogs presented with a mean duration of 8 weeks of lameness and monoparesis, with a mean age of 50.6 months. German Shepherds were overrepresented (4/15 cases).
  • MRI consistently showed contrast-enhancing, T2W, and STIR hyperintense lesions, frequently involving the L7 and T1 nerves/roots. Albuminocytological dissociation was noted in 4/5 dogs on CSF analysis.
  • All dogs responded to medical treatment, though 3 experienced relapses during a median follow-up of 25 months.

Conclusions:

  • PSRRN should be considered in dogs exhibiting diffuse spinal nerve and nerve root enlargement with chronic monoparesis.
  • While MRI findings are suggestive of PSRRN, they are not pathognomonic, underscoring the importance of including inflammatory conditions in the differential diagnosis for spinal nerve enlargement.