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  1. Home
  3. Spatial Transcriptomics And Bulk Rna-seq Analysis Revealed Molecular Classification Of Invasive Lobular Carcinoma.
  1. Home
  3. Spatial Transcriptomics And Bulk Rna-seq Analysis Revealed Molecular Classification Of Invasive Lobular Carcinoma.

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Spatial Transcriptomics and Bulk RNA-Seq Analysis Revealed Molecular Classification of Invasive Lobular Carcinoma.

Momoko Tokura1, Jun Nakayama1,2, Hironori Suzuki1,3

  • 1Laboratory of Integrative Oncology, National Cancer Center Research Institute, Tokyo, Japan.

Cancer Science
|May 21, 2026

View abstract on PubMed

Summary
This summary is machine-generated.

Pleomorphic invasive lobular carcinoma (ILC) shows worse prognosis and distinct molecular features, including heat stress response. ILC exhibits three molecular subtypes (proliferative, immunoreactive, stroma-rich) that better predict prognosis than histological classification.

Keywords:
breast cancerclassic invasive lobular carcinomamolecular classificationpleomorphic invasive lobular carcinomaspatial transcriptomics

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Optimization of a Multiplex RNA-based Expression Assay Using Breast Cancer Archival Material
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Optimization of a Multiplex RNA-based Expression Assay Using Breast Cancer Archival Material

Published on: August 1, 2018

Area of Science:

  • Oncology
  • Genomics
  • Molecular Biology

Background:

  • Invasive lobular carcinoma (ILC) is a distinct breast cancer subtype with variable histological features and prognoses.
  • Pleomorphic-ILC (P-ILC) is associated with a worse prognosis compared to classic-ILC (C-ILC) due to high-grade nuclear atypia.
  • The molecular underpinnings differentiating P-ILC from C-ILC are not well understood.

Purpose of the Study:

  • To investigate the molecular differences between C-ILC and P-ILC.
  • To identify molecular subtypes of ILC and their prognostic implications.
  • To explore potential diagnostic markers and therapeutic targets for ILC.

Main Methods:

  • Spatial transcriptomic profiling was performed on fresh-frozen C-ILC and P-ILC samples.
  • Bulk RNA-sequencing datasets were used to confirm reproducibility.
  • Molecular clustering analysis was conducted on differentially expressed genes.

    • Main Results:

    • P-ILC showed significant enrichment of cellular response to heat stress.
    • Three molecular subtypes of ILC were identified: proliferative (PR), immunoreactive (IM), and stroma-rich (ST).
    • PR subtypes were associated with P-ILC, while ST subtypes were associated with C-ILC, and these subtypes correlated with distinct prognostic outcomes.

    Conclusions:

    • Molecular profiling may offer a more accurate prognostic assessment for ILC than traditional histological classification.
    • The identified molecular subtypes and pathways (e.g., heat stress response) may serve as potential diagnostic markers and therapeutic targets for ILC.
    • Current treatment strategies for ILC do not sufficiently consider molecular subtype classification.