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Related Concept Videos

Cancer Prevention02:59

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Cancer Prevention02:59

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Preventive Healthcare Services01:30

Preventive Healthcare Services

Preventive healthcare services keep people healthy via frequent check-ups, screening, and counseling. They primarily aid in disease prevention rather than treating an acute or chronic illness. Preventive treatment also keeps individuals productive and energetic, allowing them to work well into their retirement years. Examples of preventive care services include:
Cancer Vaccines01:30

Cancer Vaccines

Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Pigmentation01:19

Pigmentation

The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...

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Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model
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Published on: September 7, 2013

Skin Cancer: Screening and Prevention.

Michelle Nelson1, Remi K Hamel2, Jennifer Nash3

  • 1Michigan State University College of Human Medicine, East Lansing.

FP Essentials
|May 21, 2026
PubMed
Summary
This summary is machine-generated.

Skin cancer is common, with basal cell carcinoma being the most frequent type. While sun protection is key for prevention, current screening methods lack sufficient evidence, and new technologies show early promise.

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Area of Science:

  • Dermatology and Oncology
  • Public Health and Preventive Medicine

Background:

  • Skin cancer is the most prevalent cancer in the U.S., with basal cell carcinoma (BCC) being the most common type across all demographics.
  • Cutaneous squamous cell carcinoma (cSCC) disproportionately affects individuals with darker skin tones, while cutaneous melanoma (CM), though less common, poses a significant lethal threat, often diagnosed at later stages in darker-skinned populations.
  • Ultraviolet (UV) radiation exposure is identified as the primary risk factor for skin cancer development.

Purpose of the Study:

  • To review the current landscape of skin cancer screening, prevention, and emerging technologies.
  • To highlight disparities in skin cancer incidence and outcomes among different racial and ethnic groups.
  • To discuss the efficacy and limitations of various preventive measures and chemopreventive agents.

Main Methods:

  • Review of existing literature and guidelines regarding skin cancer screening, including recommendations from the U.S. Preventive Services Task Force (USPSTF).
  • Evaluation of the reliability and utility of smartphone applications, artificial intelligence (AI), and teledermatology for skin cancer detection and screening.
  • Analysis of the effectiveness of sun protection strategies and chemopreventive agents like oral nicotinamide and systemic retinoids.

Main Results:

  • The USPSTF found insufficient evidence to recommend routine visual skin cancer screening in asymptomatic individuals.
  • Smartphone apps are deemed unreliable for skin cancer detection; AI and teledermatology show potential for triage and access but are not standard for population screening.
  • Sun protection measures (education, sunscreen, protective clothing, sun avoidance) remain the cornerstone of prevention. Oral nicotinamide is effective in reducing new nonmelanoma skin cancers in high-risk patients.

Conclusions:

  • Effective skin cancer prevention relies on established sun protection methods and public education.
  • Current evidence does not support routine population-level screening, necessitating further research into reliable screening tools and technologies.
  • Chemoprevention with oral nicotinamide offers a viable strategy for high-risk individuals, while other agents require careful consideration due to potential adverse effects.