Related Experiment Video

Updated: May 23, 2026

Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor (LATS) Biosensor
07:16

Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor (LATS) Biosensor

Published on: September 13, 2018

LATS kinase activity and tumor suppressor function are regulated by a second autophosphorylation site

Ruxin Jin1, Zhenxing Zhong1, Rui Zhu1

  • 1Institute of Pediatrics, Children's Hospital of Fudan University, Qidong-Fudan Innovative Institution of Medical Sciences, and Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai, China.

The Journal of Biological Chemistry
|May 21, 2026
PubMed
Abstract

Keywords:
Hippo signaling pathwayLATS1/2YAP/TAZactivation loopautophosphorylationcanonical LATS1/2 substrate sitehydrophobic motifkinase activity

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