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Burden of non-cancer comorbidities and mortality in chronic pancreatitis: a retrospective cohort study

Shauntelle Quammie1,2, Adil Rashid1,3, Rahul Munyal4

  • 1NIHR Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust and University of Nottingham, Nottingham, UK.

BMJ Open Gastroenterology
|May 21, 2026
PubMed

Insights

Patients with chronic pancreatitis (CP) face significantly higher risks of serious comorbidities like heart failure and diabetes. This progressive disease also leads to substantially increased mortality rates compared to the general population.

Area of Science:

  • Gastroenterology and Hepatology
  • Epidemiology
  • Internal Medicine

Background:

  • Chronic pancreatitis (CP) is a severe fibro-inflammatory condition.
  • CP is linked to increased comorbidities and mortality.
  • Understanding the natural history of CP is crucial for patient management.

Purpose of the Study:

  • To characterize the natural history of chronic pancreatitis.
  • To assess comorbidity prevalence in a CP cohort.
  • To evaluate mortality rates in patients with CP.

Main Methods:

  • Retrospective cohort study at Nottingham University Hospitals NHS Trust.
  • Included patients diagnosed with CP between 2006 and 2014.
  • Follow-up until May 2023, comparing comorbidity and mortality with national data.

Main Results:

  • Patients with CP showed significantly elevated standardized prevalence ratios (SPRs) for heart failure, diabetes mellitus, ischemic heart disease, atrial fibrillation, and cerebrovascular disease.
  • Cumulative incidence at 20 years for diabetes mellitus, chronic liver disease, and chronic kidney disease was 11-12%.
  • A high mortality rate was observed, with a standardized mortality ratio (SMR) of 2.3 compared to the general population. Leading causes of death included malignancy, infections, and cardiovascular disease.

Conclusions:

  • Chronic pancreatitis is associated with a significantly increased risk of multiple comorbidities.
  • Patients with CP experience elevated mortality rates compared to the general population.
  • Enhanced surveillance and early intervention strategies are recommended to manage CP-associated conditions.
Abstract

Keywords:
CARDIOVASCULAR DISEASECHRONIC LIVER DISEASECHRONIC PANCREATITISDIABETES MELLITUS

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