PsiConnect: Multimodal Neuroimaging of Context-Dependent Brain and Behaviour Dynamics under Psilocybin

Area of Science:

• Neuroscience
• Psychopharmacology
• Cognitive Science

Background:

• Psilocybin's effects on the brain are complex and context-dependent.
• Understanding these effects requires multimodal neuroimaging and diverse experimental conditions.

Purpose of the Study:

• To investigate the neural and subjective effects of psilocybin in various contexts.
• To explore the interaction between meditation, psilocybin, and brain function.
• To provide a comprehensive dataset for psilocybin research.

Main Methods:

• Large-scale study with 62 participants using multimodal neuroimaging (fMRI, dMRI, EEG).
• Psilocybin administration (19 mg) with resting-state and naturalistic conditions (meditation, music, movie).
• Multi-echo fMRI for enhanced data quality; comprehensive behavioral and self-report measures.

Main Results:

• Detailed analysis of psilocybin's impact on brain activity and connectivity across contexts.
• Assessment of acute and longitudinal cognitive and subjective changes.
• Exploration of how meditation training modulates psilocybin's effects.

Conclusions:

• PsiConnect offers a robust, multimodal dataset for understanding psilocybin's context-dependent effects.
• The study enhances the reliability of neuroimaging data through advanced techniques.
• Open science principles ensure data accessibility for future cognitive and computational neuroscience research.