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Related Concept Videos

The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
Aging01:26

Aging

Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Renewal of Skin Epidermal Stem Cells01:12

Renewal of Skin Epidermal Stem Cells

The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular cells,...
Replicative Cell Senescence02:15

Replicative Cell Senescence

Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds the telomeric...
Replicative Cell Senescence02:15

Replicative Cell Senescence

Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds the telomeric...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...

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Related Experiment Video

Updated: May 23, 2026

Enhancement of Facial Rejuvenation Through a Combination of 1565 nm Non-Ablative Fractional Laser with 30% Supramolecular Salicylic Acid
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Enhancement of Facial Rejuvenation Through a Combination of 1565 nm Non-Ablative Fractional Laser with 30% Supramolecular Salicylic Acid

Published on: September 27, 2024

Skin aging: mechanisms, evaluation, and rejuvenation.

Runhan Li1, Jingyun Zhang2, Kehang Mao1,3

  • 1Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Center for Quantitative Biology (CQB), Peking University, Beijing, 100871, China.

The EMBO Journal
|May 21, 2026
PubMed
Summary

Skin aging is a visible sign of body aging, impacting tissue health and longevity. This study explores skin aging mechanisms and rejuvenation strategies for better health.

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Last Updated: May 23, 2026

Enhancement of Facial Rejuvenation Through a Combination of 1565 nm Non-Ablative Fractional Laser with 30% Supramolecular Salicylic Acid
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Enhancement of Facial Rejuvenation Through a Combination of 1565 nm Non-Ablative Fractional Laser with 30% Supramolecular Salicylic Acid

Published on: September 27, 2024

Human Ex vivo Wound Model and Whole-Mount Staining Approach to Accurately Evaluate Skin Repair
07:32

Human Ex vivo Wound Model and Whole-Mount Staining Approach to Accurately Evaluate Skin Repair

Published on: February 17, 2021

Area of Science:

  • Gerontology
  • Dermatology
  • Molecular Biology

Background:

  • Skin aging is a visible indicator of systemic aging, affecting tissue homeostasis, barrier integrity, immune defense, and regeneration.
  • Understanding skin aging mechanisms provides insights into overall organismal aging and longevity.
  • Key factors include cellular senescence, disrupted communication between skin layers, and dysregulated microbiome and hormonal signaling.

Purpose of the Study:

  • To dissect the multi-layered mechanisms driving skin aging across epidermal, dermal, and appendage compartments.
  • To summarize advances in quantitative evaluation of skin aging for objective biological age assessment.
  • To highlight novel rejuvenation strategies for precision interventions and regenerative therapies.

Main Methods:

  • Analysis of intrinsic cellular senescence and inter-compartmental communication pathways.
  • Evaluation of skin microbiome and hormonal signaling dysregulation.
  • Review of quantitative assessment methods including molecular, morphological, microbial, and phenotypic indices.

Main Results:

  • Intrinsic cellular senescence, disrupted communication, and dysregulated microbiome/hormonal signaling collectively impair skin structure and function.
  • Quantitative evaluation methods enable objective assessment of biological age and intervention effectiveness.
  • Multiple rejuvenation strategies show promise for rewiring gene expression, modulating metabolism, remodeling the microenvironment, and regulating hormones.

Conclusions:

  • Skin aging is a complex process involving cellular, microbial, and hormonal factors across skin compartments.
  • Objective assessment tools are advancing the understanding and measurement of skin aging.
  • Precision rejuvenation strategies offer a framework for next-generation regenerative therapies targeting skin aging.