Treat-to-target in Behçet syndrome

Area of Science:

• Rheumatology and Immunology
• Systemic Vasculitis
• Autoimmune Diseases

Background:

• Behçet syndrome is a complex systemic immune-mediated vasculitis with varied manifestations.
• The treat-to-target (T2T) approach is crucial for systemic autoimmune rheumatic diseases but underexplored in Behçet syndrome.
• Clinical trial advancements highlight the need for a T2T strategy in Behçet syndrome management.

Purpose of the Study:

• To propose an evidence-based treat-to-target (T2T) strategy for Behçet syndrome.
• To define organ-specific treatment goals, outcome measures, and remission/relapse criteria.
• To establish monitoring strategies and treatment targets for Behçet syndrome.

Main Methods:

• Multidisciplinary collaboration of international experts (rheumatologists, immunologists, ophthalmologists, gastroenterologists, neurologists).
• Organ-based approach to identify and address challenges in Behçet syndrome management.
• Evidence-based review and synthesis to formulate T2T recommendations.

Main Results:

• Defines specific treatment targets for organ involvement in Behçet syndrome.
• Proposes outcome measures for remission and relapse definitions.
• Suggests monitoring strategies and treatment targets for effective disease control.

Conclusions:

• A treat-to-target (T2T) strategy is essential for optimizing Behçet syndrome management.
• This evidence-based perspective provides a framework for future research and clinical practice.
• Implementing T2T in Behçet syndrome aims to enhance patient outcomes and disease control.