Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: May 23, 2026

Magnetic Resonance Imaging Assessment of Carcinogen-induced Murine Bladder Tumors
05:19

Magnetic Resonance Imaging Assessment of Carcinogen-induced Murine Bladder Tumors

Published on: March 29, 2019

Integrating machine learning and structural analysis to decipher benzo[a]pyrene-induced bladder cancer networks.

Xinzhao Zhao1, Ruize Qin1, Chengquan Shen1

  • 1Department of Urology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.

Discover Oncology
|May 21, 2026
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

NOTCH3 regulates myofibroblastic CAF differentiation via the P62-ROS signaling axis to promote bladder cancer progression.

Journal of experimental & clinical cancer research : CR·2026
Same author

Targeting RRBP1 reverses immune evasion and enhances immunotherapy efficacy via the CXCL10-CXCR3 axis in bladder cancer.

Journal for immunotherapy of cancer·2026
Same author

Combining machine learning and molecular docking to unravel the molecular network of bladder cancer induced by 2-naphthylamine.

Discover oncology·2025
Same author

Tumor-intrinsic ENO1 inhibition promotes antitumor immune response and facilitates the efficacy of anti-PD-L1 immunotherapy in bladder cancer.

Journal of experimental & clinical cancer research : CR·2025
Same author

The effectiveness and safety of RC48 alone or in combination with PD-1 inhibitors for locally advanced or metastatic urothelial carcinoma: a multicenter, real-world study.

Journal of translational medicine·2025
Same author

NOTCH3 promotes malignant progression of bladder cancer by directly regulating SPP1 and activating PI3K/AKT pathway.

Cell death & disease·2024

Benzo[a]pyrene (BaP), a pollutant linked to bladder cancer (BLCA), drives specific gene changes. This study identifies key genes like GSK3B and SKP2 involved in BaP-induced bladder cancer development.

Area of Science:

  • Environmental Health
  • Oncology
  • Toxicology

Background:

  • Benzo[a]pyrene (BaP) is a polycyclic aromatic hydrocarbon found in tobacco smoke and pollutants.
  • BaP exposure is a known risk factor for bladder cancer (BLCA).

Purpose of the Study:

  • To identify genes differentially expressed due to BaP exposure in bladder cancer.
  • To elucidate the molecular mechanisms underlying BaP-induced bladder carcinogenesis.

Main Methods:

  • Systematic analysis of Gene Expression Omnibus (GEO) datasets.
  • Integration of network toxicology, machine learning (SHAP analysis), molecular docking, molecular dynamics, and single-cell transcriptomics.
  • Prioritization of key BaP-related differentially expressed genes (DEBRGs).
Keywords:
Benzo[a]pyreneBladder cancerMachine learningMolecular dockingMolecular dynamics simulations

Related Experiment Videos

Last Updated: May 23, 2026

Magnetic Resonance Imaging Assessment of Carcinogen-induced Murine Bladder Tumors
05:19

Magnetic Resonance Imaging Assessment of Carcinogen-induced Murine Bladder Tumors

Published on: March 29, 2019

Main Results:

  • 19 significant DEBRGs were identified, with 7 key genes prioritized: GSK3B, SKP2, AURKB, EPHB4, KIT, NR3C2, and CA2.
  • GSK3B and SKP2 were highlighted by SHAP analysis as crucial for predictive modeling of BaP-mediated BLCA.
  • Single-cell transcriptomics revealed cell-type specific expression of these genes within the tumor microenvironment.
  • Molecular simulations provided insights into BaP-protein interactions.

Conclusions:

  • This study identifies critical genes involved in BaP-induced bladder cancer.
  • The findings offer potential therapeutic targets and deepen the understanding of BaP's molecular carcinogenesis pathways.