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Genetic Analysis of Hereditary Transthyretin Ala97Ser Related Amyloidosis
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A Rare Biopsy-Confirmed Case of Wild-Type Transthyretin Amyloid Polyneuropathy and Autonomic Neuropathy

Pariwat Thaisetthawatkul1, J Americo M Fernandes1, Ezequiel Piccione1

  • 1Department of Neurological Sciences, University of Nebraska Medical Center, Omaha, Nebraska, USA.

Muscle & Nerve
|May 21, 2026
PubMed
Abstract

No abstract available in PubMed .

Keywords:
autonomic neuropathypolyneuropathywild‐type transthyretin amyloid

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DefinitionDiabetic neuropathy is nerve damage caused by long-standing diabetes mellitus. It results directly from prolonged high blood sugar levels.PathophysiologyThe pathophysiology of diabetic neuropathy involves both metabolic and vascular disturbances triggered by chronic hyperglycemia.Metabolic injury: Elevated glucose levels activate the polyol pathway within nerve cells, leading to the accumulation of sorbitol and fructose. This increases oxidative stress, disrupts normal nerve...

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