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Updated: May 23, 2026

Rapid Screening of HIV Reverse Transcriptase and Integrase Inhibitors
05:46

Rapid Screening of HIV Reverse Transcriptase and Integrase Inhibitors

Published on: April 9, 2014

Use of Integrase Strand Transfer Inhibitors Among Children Living With HIV in Latin America and the Caribbean

Marco Tulio Luque1, Liping Du2, Vanessa Rouzier3

  • 1From the Departamento de Pediatria, Hospital Escuela, Tegucigalpa, Honduras.

The Pediatric Infectious Disease Journal
|May 22, 2026
PubMed

Insights

Integrase strand transfer inhibitor (INSTI) use, including dolutegravir (DTG) and raltegravir (RAL), has increased among children with HIV in Latin America and the Caribbean. Further research is needed to understand the clinical impact of these HIV treatments in pediatric populations.

Area of Science:

  • Pediatric infectious diseases
  • HIV/AIDS treatment
  • Pharmacovigilance in children

Background:

  • Limited data exist on integrase strand transfer inhibitor (INSTI) use in pediatric populations.
  • Assessing dolutegravir (DTG) and raltegravir (RAL) use and outcomes in children with HIV in Latin America and the Caribbean is crucial.

Purpose of the Study:

  • To evaluate trends and factors associated with INSTI initiation (DTG/RAL) in children with HIV.
  • To compare viral and treatment outcomes based on INSTI use in pediatric HIV care.

Main Methods:

  • Analysis of data from pediatric cohorts in Brazil, Haiti, and Honduras (2013-2022).
  • Utilized multivariable logistic and Cox regression models for ART-naïve and ART-experienced children, respectively.
  • Log-rank tests were used to compare outcomes between INSTI users and non-users in ART-naïve children.

Main Results:

  • INSTI initiation, particularly DTG, increased significantly among ART-naïve children from 2016 to 2022.
  • Older age and more recent calendar years were associated with higher DTG initiation rates in ART-naïve children.
  • No significant difference in virologic suppression was observed between DTG users and non-users, but DTG users had longer first-regimen duration.

Conclusions:

  • INSTI use has demonstrably increased among children with HIV in parts of Latin America and the Caribbean.
  • The clinical impact of INSTI regimens in pediatric HIV management requires further investigation.
Abstract

Keywords:
HIVLatin Americachildrendolutegravirraltegravir

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