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Updated: May 23, 2026

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
10:03

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Published on: January 28, 2020

Apoptotic markers and Dectin-1+ cells predict cardiac function in patients with ST-elevation myocardial infarction

Fengjing Yang1, Bingjun Shu1, Na Kuang1

  • 1Department of Cardiovascular Medicine, Wuhan Hospital Of Traditional Chinese Medicine, Wuhan, 430000, China.

BMC Cardiovascular Disorders
|May 22, 2026
PubMed

Insights

Apoptotic markers like TWEAK and TRAIL, along with Dectin-1, show promise in predicting cardiac function recovery after myocardial infarction. Combining these biomarkers offers improved prognostic value for STEMI patients post-PCI.

Area of Science:

  • Cardiology
  • Immunology
  • Biomarker Discovery

Background:

  • ST-elevation myocardial infarction (STEMI) poses significant risks to cardiac function post-percutaneous coronary intervention (PCI).
  • Identifying reliable predictors of cardiac recovery is crucial for managing STEMI patients.

Purpose of the Study:

  • To evaluate the prognostic significance of apoptotic markers and dendritic cell-associated C-type lectin-1 (Dectin-1) in predicting cardiac function improvement after PCI in STEMI patients.
  • To assess the combined predictive value of these markers for left ventricular ejection fraction (LVEF) recovery.

Main Methods:

  • Retrospective analysis of 96 STEMI patients undergoing successful PCI.
  • Categorization into LVEF improvement (≥10%) and non-improvement (<10%) groups at 30 days post-PCI.
  • Comparison of apoptotic markers (TWEAK, TRAIL) and soluble Dectin-1 levels; multivariable logistic regression analysis.

Main Results:

  • Significantly lower TWEAK and Dectin-1 levels, and higher TRAIL levels in the LVEF improvement group.
  • TRAIL and TWEAK were independently associated with LVEF improvement.
  • A combination of TRAIL, TWEAK, and soluble Dectin-1 achieved high sensitivity (78.57%) and specificity (82.35%) for predicting LVEF improvement.

Conclusions:

  • Apoptotic markers (TRAIL, TWEAK) and soluble Dectin-1 are potential predictors of cardiac function recovery in STEMI patients post-PCI.
  • The combined assessment of these biomarkers enhances prognostic accuracy.
  • Further validation in larger prospective studies is recommended.
Abstract

Keywords:
Apoptotic MarkersDectin-1 + CellsLeft ventricular ejection fractionPercutaneous Coronary InterventionST-Elevation Myocardial Infarction

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