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Metabolic Characterization of Polarized M1 and M2 Bone Marrow-derived Macrophages Using Real-time Extracellular Flux Analysis
Published on: November 28, 2015
Macrophages in Psoriasis: From Functional Heterogeneity to Metabolic Reprogramming and Novel Therapeutics
Qianzi Liu1,2,3,4,5,6,7, Yexuan Wu8, Jinru Tang1,2,3,4,5,6,7
1The Department of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Abstract:
This review provides a comprehensive overview of macrophage heterogeneity, polarisation dynamics, metabolic reprogramming and multicellular interactions of macrophages in psoriasis. We discuss how single-cell technologies have revealed diverse macrophage subsets and explore the metabolic profile of macrophages in psoriasis. Furthermore, we examine the central role of macrophages in intercellular networks with keratinocytes, T helper 17 (Th17) cells, neutrophils, fibroblasts and sensory neurons. Additionally, we summarise the novel signal way of macrophages and tissue injury by macrophages. Finally, we summarise emerging therapeutic strategies-including metabolic modulators, signalling pathway inhibitors, advanced delivery systems and cell-based therapies. By integrating recent insights from single-cell omics, spatial transcriptomics and metabolic studies, this review underscores the potential of macrophage-focused interventions for psoriasis treatment.
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