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Related Concept Videos

Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
The Functions of the Skeletal System01:22

The Functions of the Skeletal System

The most apparent functions of the skeletal system are support, protection, and movement. However, bone tissue also performs several other critical metabolic functions. For one, the bone matrix acts as a reservoir for a number of minerals important to the functioning of the body, especially calcium and phosphorus. These minerals, present in the bone tissue, can be released back into the bloodstream when required. Calcium ions, for example, are essential for muscle contractions and controlling...
Changes in the Appendicular Skeleton with Age01:09

Changes in the Appendicular Skeleton with Age

The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
What is the Skeletal System?01:02

What is the Skeletal System?

Overview
Disorders of the Skeletal Muscle01:28

Disorders of the Skeletal Muscle

The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
Essential Minerals for Bone Health01:31

Essential Minerals for Bone Health

The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...

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Related Experiment Video

Updated: May 23, 2026

Murine Hind Limb Long Bone Dissection and Bone Marrow Isolation
07:17

Murine Hind Limb Long Bone Dissection and Bone Marrow Isolation

Published on: April 14, 2016

m6A modification in skeletal system diseases (Review).

Xi Xie1, Chen Li2, Haotian Zheng1

  • 1First Clinical Medical College, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang 150040, P.R. China.

Molecular Medicine Reports
|May 22, 2026
PubMed
Summary
This summary is machine-generated.

N6-methyladenosine (m6A) modifications regulate skeletal development and disease by balancing bone cells. Dysregulation of m6A contributes to skeletal disorders like osteoporosis and osteoarthritis.

Keywords:
N6‑methyladenosine methylationepigeneticsm6A regulatory factorskeletal system disease

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Last Updated: May 23, 2026

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Area of Science:

  • Epigenetics
  • Skeletal Biology
  • Molecular Mechanisms

Background:

  • N6-methyladenosine (m6A) is a crucial epigenetic modification in mammals.
  • m6A regulates skeletal development and is implicated in skeletal disorders.
  • The roles of many m6A factors in skeletal diseases are not fully understood.

Purpose of the Study:

  • To review the roles and mechanisms of m6A modification in skeletal diseases.
  • To highlight the therapeutic potential of m6A in skeletal conditions.
  • To provide insights for skeletal disease prevention and treatment.

Main Methods:

  • Literature review of m6A modification in skeletal biology and diseases.
  • Analysis of the regulatory roles of m6A writers, erasers, and readers.
  • Examination of m6A's impact on osteoblasts, osteoclasts, and chondrocytes.

Main Results:

  • m6A maintains bone homeostasis by balancing osteoblasts and osteoclasts.
  • Dysregulated m6A leads to increased osteoclast proliferation and chondrocyte apoptosis.
  • m6A modification affects non-coding RNAs, influencing post-transcriptional regulation in skeletal tissues.

Conclusions:

  • m6A modification plays a significant role in skeletal homeostasis and pathogenesis.
  • Aberrant m6A contributes to osteoporosis, osteoarthritis, rheumatoid arthritis, and intervertebral disc degeneration.
  • Targeting m6A pathways offers potential therapeutic strategies for skeletal disorders.