Description of invasive aspergillosis in Mexican patients with chronic granulomatous disease

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Histological Quantification to Determine Lung Fungal Burden in Experimental Aspergillosis

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Tiareth Cova-Guzmán1, Deborah Palacios Reyes2, Carla M Román-Montes3,4

  • 1Laboratory of Immunodeficiency, National Institute of Pediatrics, Mexico City, Mexico.

Journal of Human Immunity
|May 22, 2026
PubMed

Insights

Invasive aspergillosis (IA) is a major cause of mortality in chronic granulomatous disease (CGD). Early suspicion and prolonged antifungal treatment significantly improve survival rates in CGD patients with IA.

Area of Science:

  • Infectious Diseases
  • Immunology

Background:

  • Chronic granulomatous disease (CGD) patients are highly susceptible to invasive fungal infections.
  • Invasive aspergillosis (IA) is the most frequent and life-threatening fungal infection in CGD.

Purpose of the Study:

  • To analyze the clinical characteristics, treatment outcomes, and survival rates of CGD patients with IA.
  • To identify factors influencing mortality in CGD patients experiencing IA.

Main Methods:

  • Retrospective analysis of 45 CGD patients with documented invasive aspergillosis events.
  • Evaluation of mortality rates based on IA classification (proven, probable, possible) and duration of antifungal therapy.

Main Results:

  • The overall mortality rate for IA in CGD patients was high, with proven cases showing the highest mortality (57.7%).
  • Patients receiving antifungal treatment for over 75 days had significantly lower mortality (16.7%) compared to those treated for less than 75 days (36%).
  • Aspergillus fumigatus was the predominant species identified.

Conclusions:

  • Early detection and prolonged antifungal therapy are crucial for improving survival in CGD patients with IA.
  • Hematopoietic stem cell transplantation should be considered as a therapeutic option for eligible CGD patients with IA.

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