Related Experiment Video
Updated: May 23, 2026
Establishment of an Experimental Mouse Model of Endometrioma to Study its Related Infertility
Published on: April 5, 2024
Identification and exploration of potential N6-methylation related mRNAs in endometriosis
Yanan He1, Chengcheng Ren1, Liang Lei2
1Department of Gynecology, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
Background:
N6-methyladenosine (m6A) modification regulates the processes of RNA splicing, subcellular localization, translation and stability by changing the RNA structure and the interaction between RNA and RNA-binding proteins to ensure the timely and accurate expression of genes. In this study, we investigated m6A-related mRNAs and for the first time explored effective prevention and treatment targets in endometriosis (EM).
Methods:
By arraystar m6A-mRNA epitranscriptomic microarray, biological information analysis technologies, and validation of other databases, aberrant m6A-related mRNAs were uncovered, as well as efficient therapeutic drugs.
Results:
FN1, VCAM1, RAP1A, BRCA1, CCNA2 and CDK1 might be vital m6A-related mRNAs, and VCAM1 and RAP1A may be the most important two. A few crucial small-molecule agents supply new views for the treatment of EM.
Conclusion:
These results demonstrated novel insights into m6A modification of EM and revealed potential biomarkers and precision medicine strategies for EM.