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Updated: May 23, 2026

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
Published on: February 7, 2019
Enantioselective cyclization reactions involving 3-isothiocyanato oxindoles: synthesis of spirocycles
Mohammad Hadi Edareh1, Fatemeh Doraghi2, Arman Farahani3
1School of Chemistry, College of Science, University of Tehran Tehran Iran.
Abstract:
Recently, 3-isothiocyanato oxindoles have been used in various asymmetric cascade cyclization reactions for the synthesis of biologically important spirocyclic compounds. As a powerful and versatile ambiphilic synthon, 3-isothiocyanato oxindoles react effectively with diverse electron-deficient unsaturated bonds through Michael addition/cyclization reactions under organocatalysis or metal catalysis systems. This review highlights catalytic enantioselective cyclization reaction of 3-isothiocyanato oxindoles since 2011, and discusses their mechanistic insights.
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