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Balloon dilatation combined with thrombectomy reduces myocardial injury in massive pulmonary embolism

Yi Zheng1, Jun Deng2, Senlin Zhou3

  • 1Department of Vascular Surgery, Beiliu People's Hospital Beiliu, Guangxi, China.

American Journal of Translational Research
|May 22, 2026
PubMed
Abstract

Insights

Combined balloon dilation and thrombectomy significantly reduces myocardial injury markers and improves outcomes in massive pulmonary embolism (MPE) patients. This treatment offers better clinical efficacy and cardiac function compared to basic therapy alone.

Area of Science:

  • Cardiology
  • Pulmonary Medicine
  • Interventional Radiology

Background:

  • Massive pulmonary embolism (MPE) poses a significant risk of right heart strain and myocardial injury.
  • Current treatment strategies for MPE aim to restore pulmonary blood flow and alleviate hemodynamic compromise.

Purpose of the Study:

  • To evaluate the impact of combined balloon dilatation and thrombectomy on myocardial injury markers in MPE patients.
  • To compare the clinical efficacy and hemodynamic improvements of combined therapy versus basic therapy in MPE.

Main Methods:

  • A retrospective analysis of 90 MPE patients was performed.
  • Patients were divided into a combined treatment group (balloon dilatation + thrombectomy) and a basic treatment group.
  • Clinical outcomes, Miller scores, pulmonary artery pressure (PAP), pulmonary artery diameter (PAD), and myocardial injury markers (myoglobin, troponin T, creatine kinase, fibrinogen) were assessed.

Main Results:

  • The combined treatment group showed significantly higher response rates and improved clinical efficacy compared to the basic treatment group.
  • Hemodynamic parameters, including Miller score, PAP, PAD, and RV/LV ratio, were significantly improved post-treatment in the combined group.
  • Myocardial injury markers (MYO, TnT, CK, FIB) were significantly reduced in the combined treatment group at specific time points.
  • Correlations were found between CK and PaCO2, and TnT and PaO2, indicating a link between injury markers and gas exchange.

Conclusions:

  • Balloon dilatation combined with thrombectomy is an effective treatment for MPE.
  • This combined approach significantly reduces myocardial injury and inflammation markers.
  • The intervention leads to marked improvements in clinical outcomes and cardiac function in MPE patients.
Keywords:
Balloon dilationembolismmassive pulmonary embolismreperfusion injury

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