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Prognostic Value of Systemic Immune-Inflammation Index (SII) in Hospital Readmission Following Acute Myocardial
Yasaman Borghei1, Bahare Gholami-Chaboki1, Nasibe Goli1
1Department of Cardiology, Cardiovascular Diseases Research Center, Heshmat Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran, gums.ac.ir.
Background:
Acute myocardial infarction (AMI) initiates an inflammatory response essential for cardiac repair. Several novel inflammatory markers have been identified as indicators of systemic inflammation, including the systemic immune-inflammation index (SII). This study aimed to evaluate the relationship between SII levels and readmission rates in AMI patients.
Methods:
This retrospective cohort study analyzed 1147 AMI patients admitted between 2019 and 2021. The optimal SII cutoff was determined as 694.3 × 109/L, categorizing patients into high SII (≥ 694.3) and low SII (< 694.3) groups. The association between SII levels and readmission risk was assessed using a logistic regression model.
Results:
Over 4 years, 454 patients were readmitted, with higher readmission rates (34.4%) observed in the high SII group. Statistically significant differences were noted in primary outcomes, with higher SII patients experiencing increased incidence of major adverse cardiovascular events (MACEs) (p < 0.05). The Cox proportional hazards model indicated that individuals with prior CABG had a 40% higher risk of readmission.
Conclusion:
Although patients with high SII demonstrated higher hospital readmission rates, primarily due to recurrent MI, no statistically significant association was observed.
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