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Retraction: Comparing calpain- and caspase-3-mediated degradation patterns in traumatic brain injury by differential

Kevin K W Wang1, Ming Cheng Liu1, Veronica Akle1

  • 1Center for Neuroproteomics and Biomarkers Research, Department of Psychiatry, McKnight Brain Institute, University of Florida, P.O. Box 100256, Gainesville, FL 32610, U.S.A.

The Biochemical Journal
|May 22, 2026
PubMed
Abstract

No abstract available in PubMed .

Keywords:
calpaincaspasedegradomehigh throughput immunoblotting (HTPI)proteomicstraumatic brain injury (TBI)

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Caspases

Caspase, a family of cysteine proteases, serve as effectors in apoptosis. The ced3 gene in C.elegans was first identified to be involved in apoptosis. This gene encodes the ced-3 caspase that is similar to the interleukin-1-beta converting enzyme or ICE in mammals. In addition to apoptosis, caspases also function in the inflammatory response. Inflammatory caspases are essential in activating pro-inflammatory cytokines that recruit immune cells and block the replication of pathogens inside cells.