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Updated: May 23, 2026

Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
Radical bromination/cascade cyclization: a facile approach towards benzimidazole-fused isoquinolinones
Hong Zhang1, Qi Yue1, Zhenyu Yao1
1Engineering Research Centre of Molecular Medicine of Ministry of Education, Key Laboratory of Fujian Molecular Medicine, Key Laboratory of Precision Medicine and Molecular Diagnosis of Fujian Universities, Key Laboratory of Xiamen Marine and Gene Drugs, School of Biomedical Sciences, Huaqiao University, Xiamen 361021, P. R. China. cuixl@hqu.edu.cn.
None:
A radical bromination/cyclization strategy has been developed for the synthesis of brominated benzimidazo[2,1-a]isoquinolin-6(5H)-ones by utilizing tetrabutylammonium bromide (TBAB) as a safe and cheap bromide source. It demonstrates efficiency in the first reported construction of these brominated scaffolds with good functional group tolerance, enabling the direct introduction of a bromine atom which was suited for late-stage functionalization, underscoring its potential for further derivatization in the synthesis of complex molecules.
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