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Updated: May 23, 2026

Palladium N-Heterocyclic Carbene Complexes: Synthesis from Benzimidazolium Salts and Catalytic Activity in Carbon-carbon Bond-forming Reactions
Published on: July 30, 2017
Palladium-catalysed regioselective [4 + 2] annulation to access silatetralin-1-amines
Yan Sun1, Ruiqiang Lu1, Hang Zhou1
1School of Chemistry and Materials, Yangzhou University, Yangzhou, Jiangsu 225002, China. gaoliuzhou@yzu.edu.cn.
Abstract:
A palladium-catalysed [4 + 2] annulation of benzosilacyclobutenes with N-allenamides for the synthesis of silatetralin-1-amines is reported. This protocol utilizes N-allenamides as versatile bifunctional reagents, acting as both two-carbon synthons and nitrogen donors. The reaction provides efficient access to structurally diverse silatetralin-1-amines in good yields with high functional group compatibility. Notably, the transformation is characterized by exclusive proximal CC bond insertion with regioselective Si-C(sp2) bond cleavage of benzosilacyclobutenes.
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