Nickel/copper co-catalysed atroposelective C-Si cross-coupling for the synthesis of axially chiral heterobiaryl silanes
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Updated: May 23, 2026

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
Published on: February 7, 2019
Lei Su1, Shen Gao1, Jiawang Liu1
1Frontiers Science Center for Transformative Molecules, State Key Laboratory of Synergistic Chem-Bio Synthesis, Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China. gaoshen2000@sjtu.edu.cn.
Abstract:
Organosilanes, especially their chiral derivatives, play increasingly vital roles in organic synthesis and materials science. However, general methods for their asymmetric synthesis remain limited. Existing approaches to axially chiral silanes largely rely on noble-metal catalysis. Here, we report a Ni/Cu-co-catalyzed atroposelective C(sp2)-Si cross-coupling of heterobiaryl triflates with Si-B reagents, providing efficient access to axially chiral silanes. This method offers a broad substrate scope and operational simplicity, establishing a sustainable strategy for constructing valuable chiral silicon-based compounds.
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