Related Experiment Video
Updated: May 23, 2026

A Two-Step Protocol for Umpolung Functionalization of Ketones Via Enolonium Species
Published on: August 16, 2018
Photochemical chloro-sulfoximidation of bicyclo[1.1.1]pentane with sulfonimidoyl chlorides
Gao-Feng Yang1, Mengting Kou1, Zhi Liu1
1State Key Laboratory of Coordination Chemistry, Jiangsu Key Laboratory of Advanced Organic Materials, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry, Nanjing University, Nanjing 210023, China. lwp1989@nju.edu.cn.
Abstract:
Bicyclo[1.1.1]pentane (BCP) and sulfoximines are versatile bioisosteres in organic synthesis and medicinal chemistry. However, direct synthetic methods for accessing disubstituted BCP sulfoximines remain limited. Herein, we report a general platform that addresses this challenge by enabling sulfonimidoyl chlorides to participate in photochemical coupling reactions with BCP, thereby providing efficient access to sulfoximine-BCP chloro hybrid bioisosteres.
Related Concept Videos
Preparation and Reactions of Sulfides
Carboxylic Acids to Acid Chlorides
Electrophilic Aromatic Substitution: Sulfonation of Benzene
Electrophilic Aromatic Substitution: Fluorination and Iodination of Benzene
Preparation and Reactions of Thiols
Cycloaddition Reactions: MO Requirements for Photochemical Activation
![Cercosporin-Photocatalyzed [4+1]- and [4+2]-Annulations of Azoalkenes Under Mild Conditions](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F60786.jpg&w=3840&q=50)