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Acyclic cucurbituril as sequestrant for acetaminophen.

Jeppe S Mogensen1, Thomas M Hofmann2, Suvenika Perera2

  • 1Department of Chemistry, University of Copenhagen, Universitetsparken 5, DK-2100 Copenhagen Ø, Denmark. pittel@chem.ku.dk.

Chemical Communications (Cambridge, England)
|May 22, 2026
PubMed
Summary
This summary is machine-generated.

A novel acyclic host H4 effectively removes pharmaceutical micropollutants from water, achieving 99.8% acetaminophen removal in 5 minutes. It matches activated charcoal performance in simulated gastric fluid, offering a promising water purification solution.

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Area of Science:

  • Supramolecular Chemistry
  • Environmental Science
  • Materials Science

Background:

  • Pharmaceutical micropollutants (PMs) pose risks to aquatic ecosystems and human health.
  • Current water treatment methods for PMs can be inefficient or costly.
  • Cyclodextrin-based hosts are known for pollutant sequestration.

Purpose of the Study:

  • To investigate the efficacy of acyclic CB[n]-type host H4 as a solid-state sequestrant for PMs in water.
  • To evaluate the performance of H4 compared to activated charcoal for acetaminophen removal.
  • To assess H4's potential for water purification applications.

Main Methods:

  • Synthesis and characterization of acyclic CB[n]-type host H4.
  • Batch adsorption experiments to determine PM removal efficiency and kinetics.
  • Comparative analysis of H4 and activated charcoal (DARCO®) using simulated gastric fluid.

Main Results:

  • Acyclic host H4 demonstrated high removal efficiency for acetaminophen, reaching 99.8% within 5 minutes.
  • H4 exhibited comparable or superior performance to activated charcoal in sequestering acetaminophen from simulated gastric fluid.
  • The solid-state nature of H4 facilitates its application as a water treatment agent.

Conclusions:

  • Acyclic CB[n]-type host H4 is a highly efficient solid-state sequestrant for pharmaceutical micropollutants.
  • H4 presents a viable alternative to conventional adsorbents like activated charcoal for water purification.
  • Further research into H4's application in real-world water treatment scenarios is warranted.