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Related Concept Videos

Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...
Tissue Transplantation01:24

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...
Blood Transfusion01:15

Blood Transfusion

Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...

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Related Experiment Video

Updated: May 23, 2026

Lung Rapid Recovery Procurement Combined with Abdominal Normothermic Regional Perfusion in Controlled Donation after Circulatory Death
09:54

Lung Rapid Recovery Procurement Combined with Abdominal Normothermic Regional Perfusion in Controlled Donation after Circulatory Death

Published on: August 15, 2022

Infectious Risk Donor Status in Uncontrolled Donation After Circulatory Death and Liver Transplantation.

Chiara Lazzeri1, Paolo Antonio Grossi2, Manuela Bonizzoli3

  • 1Regional Center for Transplant Coordination, Florence, Italy.

Transplant Infectious Disease : an Official Journal of the Transplantation Society
|May 22, 2026
PubMed
Summary

Uncontrolled donation after circulatory death (uDCD) donors pose a low infection risk for liver transplant recipients. Careful donor evaluation is crucial, and prompt antibiotic therapy for recipients is recommended if donor cultures are positive.

Keywords:
infectiousliver transplantoutcomeuncontrolled donation after circulatory death

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Area of Science:

  • Transplantation Science
  • Infectious Disease Epidemiology
  • Organ Donor Management

Background:

  • Limited data exist on infectious risk in uncontrolled donation after circulatory death (uDCD) donors.
  • High incidence of infectious complications in out-of-hospital cardiac arrest patients necessitates understanding donor infectious risk.

Purpose of the Study:

  • To assess the infectious risk profile of utilized uDCD donors.
  • To evaluate the outcomes of liver transplant recipients from uDCD donors.

Main Methods:

  • Consecutive utilized uDCD donors assessed between 2018 and 2024 were analyzed.
  • Focus was placed on the infectious risk profile of donors and the outcomes in liver transplant recipients.

Main Results:

  • 16 out of 52 uDCDs had positive blood cultures, predominantly Gram-positive bacteria (88%).
  • These microorganisms were deemed contaminants and were not isolated in recipients.
  • No donor-related infections were observed in the 24 liver transplant recipients.

Conclusions:

  • uDCD donors present a low risk of infection transmission to liver transplant recipients.
  • Systematic donor evaluation is essential due to time constraints and urgent procedures.
  • Prompt reporting of positive donor cultures and timely antibiotic therapy for recipients are recommended.