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Updated: May 23, 2026

Anticancer Metal Complexes: Synthesis and Cytotoxicity Evaluation by the MTT Assay

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Published on: November 10, 2013

Mixed-ligand oxidovanadium complexes with anticancer potential.

Sanchita Das¹, Pratikshya Das Pattanayak¹, Deepika Mohapatra¹

¹Department of Chemistry, National Institute of Technology, Rourkela, 769008 Odisha, India. rupamdinda@nitrkl.ac.in.

Dalton Transactions (Cambridge, England : 2003)

|May 22, 2026

Summary

This summary is machine-generated.

This review highlights mixed-ligand oxidovanadium complexes (MLOVCs) for cancer treatment. Incorporating biologically relevant ligands enhances MLOVCs

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Area of Science:

Medicinal Chemistry
Inorganic Chemistry
Cancer Research

Background:

Vanadium compounds are recognized for their anticancer properties.
Vanadium complexes (VCs) offer structural versatility due to coordination flexibility.
Existing reviews lack focus on mixed-ligand oxidovanadium complexes (MLOVCs) in anticancer research.

Purpose of the Study:

To summarize recent advancements in synthesizing MLOVCs.
To organize MLOVCs based on ligands and oxidation states.
To guide the development of novel vanadium-based anticancer metallodrugs.

Main Methods:

Review of recent literature on MLOVC synthesis.
Classification of MLOVCs by ligand type and oxidation level.
Analysis of structure-activity relationships for anticancer potential.

Main Results:

MLOVCs synthesized under various conditions with diverse ligands.
Correlation between biologically relevant ligands and improved complex properties (stability, solubility, cell uptake).
Demonstrated potential of MLOVCs as anticancer agents.

Conclusions:

MLOVCs represent a promising class of metallodrugs for cancer therapy.
Optimizing ligand design is crucial for enhancing MLOVC efficacy and selectivity.
Further research can advance the development of vanadium-based anticancer agents.