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Congenital Pulmonary Malformation-Management and Long-Term Outcomes of a Danish Cohort

Dalia Karzoun1,2, Anette Højsgaard3, Olav Bjørn Petersen4,5

  • 1Childrens Center of Pediatric Pulmonology and Allergology, Department of Pediatrics and Adolescent Medicine, Aarhus University Hospital, Aarhus, Denmark.

Pediatric Pulmonology
|May 22, 2026
PubMed

Insights

Congenital Pulmonary Malformations (CPMs) management varies. Surgical resection is common for symptomatic cases, while conservative management shows positive outcomes for asymptomatic children, indicating a need for individualized treatment strategies.

Area of Science:

  • Pediatric Surgery
  • Neonatal Care
  • Pulmonology

Background:

  • Congenital Pulmonary Malformations (CPMs) incidence is rising due to improved prenatal diagnostics.
  • Management strategies for asymptomatic CPMs remain debated.
  • This study evaluates management and outcomes in a Danish cohort.

Purpose of the Study:

  • To describe the management and treatment of Congenital Pulmonary Malformations (CPMs).
  • To report long-term outcomes for children diagnosed with CPMs.
  • To analyze outcomes based on prenatal or postnatal diagnosis.

Main Methods:

  • Retrospective cohort study of 47 CPM cases (2000-2016).
  • Data integrated from fetal medicine, hospital registers, and medical records.
  • Analysis of diagnosis, management, and treatment in a Danish cohort.

Main Results:

  • Surgical resection was performed in ~50% of prenatally diagnosed and 73% of postnatally diagnosed CPMs.
  • Surgery was primarily for symptomatic lesions presenting before age 1.
  • Conservatively managed asymptomatic children showed no adverse outcomes at ~4.6 years follow-up.

Conclusions:

  • Surgical intervention is frequently employed for CPMs, particularly symptomatic cases.
  • Conservative management appears safe and effective for asymptomatic CPMs.
  • Individualized management approaches are crucial for CPM patients.
Abstract

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