Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Reimagining Nodal Staging in Colorectal Cancer: Toward a Novel Non-Invasive Imaging Approach.

Cancers·2026
Same author

Platelet Transfusion Practices for Critically Ill Children: A 28-Day Point-Prevalence Study in Three European Countries in 2023.

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·2026
Same author

Dynamic thymidine kinase activity independently captures treatment-specific biological response and is independently associated with outcomes in endocrine-resistant HR+ /HER2 - metastatic breast cancer: A translational analysis of the GEICAM/2013-02 PEARL trial.

European journal of cancer (Oxford, England : 1990)·2026
Same author

DefSynUS: Real-time patient-specific intrahepatic vessel identification via deformation-aware CT-US domain adaptation.

International journal of computer assisted radiology and surgery·2026
Same author

Spatiotemporal trends of neglected tropical disease hospitalizations in Ecuador over 25-years from 2000 to 2024.

PLoS neglected tropical diseases·2026
Same author

A differentiable simulation of the eye for patient-specific strabismus surgery planning.

International journal of computer assisted radiology and surgery·2026

Related Experiment Video

Updated: May 23, 2026

Application of Laparoscopic Hepatectomy Combined with Intraoperative Microwave Ablation in Colorectal Cancer Liver Metastasis
04:22

Application of Laparoscopic Hepatectomy Combined with Intraoperative Microwave Ablation in Colorectal Cancer Liver Metastasis

Published on: March 3, 2023

Personalization of liver microwave ablation simulation.

Francesco Dettori1, Ilias Nahmed2, Michel Duprez2

  • 1MIMESIS team, Inria, Strasbourg, France. francesco.dettori@inria.fr.

International Journal of Computer Assisted Radiology and Surgery
|May 22, 2026
PubMed
Summary

Personalized blood flow modeling significantly improves predictions for microwave ablation (MWA) liver tumor treatment. This study demonstrates that patient-specific perfusion data is crucial for accurate thermal simulations and better treatment planning.

Keywords:
Finite element modelingLiver perfusionMicrowave ablationSimulation personalization

More Related Videos

Evaluation of the Feasibility, Safety, and Accuracy of an Intraoperative High-intensity Focused Ultrasound Device for Treating Liver Metastases
05:56

Evaluation of the Feasibility, Safety, and Accuracy of an Intraoperative High-intensity Focused Ultrasound Device for Treating Liver Metastases

Published on: January 9, 2019

Thermal Ablation for the Treatment of Abdominal Tumors
07:16

Thermal Ablation for the Treatment of Abdominal Tumors

Published on: March 7, 2011

Related Experiment Videos

Last Updated: May 23, 2026

Application of Laparoscopic Hepatectomy Combined with Intraoperative Microwave Ablation in Colorectal Cancer Liver Metastasis
04:22

Application of Laparoscopic Hepatectomy Combined with Intraoperative Microwave Ablation in Colorectal Cancer Liver Metastasis

Published on: March 3, 2023

Evaluation of the Feasibility, Safety, and Accuracy of an Intraoperative High-intensity Focused Ultrasound Device for Treating Liver Metastases
05:56

Evaluation of the Feasibility, Safety, and Accuracy of an Intraoperative High-intensity Focused Ultrasound Device for Treating Liver Metastases

Published on: January 9, 2019

Thermal Ablation for the Treatment of Abdominal Tumors
07:16

Thermal Ablation for the Treatment of Abdominal Tumors

Published on: March 7, 2011

Area of Science:

  • Medical physics
  • Biomedical engineering
  • Oncology

Background:

  • Microwave ablation (MWA) is a key treatment for liver tumors.
  • Accurate prediction of tissue necrosis in MWA is limited by simplified blood flow models.
  • Current models often use volumetric perfusion, lacking personalization and clinical validation.

Purpose of the Study:

  • To evaluate the impact of perfusion modeling on MWA prediction accuracy.
  • To develop and validate a patient-specific personalization framework for MWA.
  • To improve the prediction of tissue necrosis in liver tumor ablation.

Main Methods:

  • In vivo porcine liver MWA performed near large vessels.
  • Finite element simulations using the Pennes bioheat equation.
  • Developed a two-compartment tissue model with calibrated perfusion coefficients and a vessel radius model.

Main Results:

  • Significant inter-subject variability in optimal liver perfusion coefficients observed.
  • Personalized perfusion modeling improved Dice similarity by up to 55% and Hausdorff distance by over 70%.
  • Radius-dependent vessel perfusion enhanced accuracy near major vessels; thermal/electrical property variations had minor effects.

Conclusions:

  • Personalized blood perfusion modeling is essential for accurate MWA outcome prediction.
  • Perfusion modeling is the primary source of uncertainty in thermal simulations.
  • The proposed framework enables patient-specific digital twins for liver ablation planning.