Related Experiment Video

Updated: May 24, 2026

Purification of the Membrane Compartment for Endoplasmic Reticulum-associated Degradation of Exogenous Antigens in Cross-presentation
12:48

Purification of the Membrane Compartment for Endoplasmic Reticulum-associated Degradation of Exogenous Antigens in Cross-presentation

Published on: August 21, 2017

Mitochondrial complex I activity promotes antigen cross-presentation in dendritic cells

Sofía C Khouili1,2, Elena Priego1,3, Ignacio Heras-Murillo1

  • 1Immunobiology Laboratory. Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spain.

Science Immunology
|May 22, 2026
PubMed
Summary

Mitochondrial complex I (CI) is crucial for dendritic cell (DC) antigen cross-presentation. Restoring the NAD+/NADH ratio in CI-deficient DCs rescued this essential immune function.

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