Relationship between lipid profile and liver enzymes in cholelithiasis, cholesterolosis, and cholesterol polyp cases

The aim of this study is to investigate the relationship between liver enzymes and lipid profiles in cholecystectomy cases with cholecystitis, cholesterolosis, and cholesterol polyps.

The cholecystectomy cases were divided into 3 groups according to their pathological diagnosis; cholesterolosis and cholelithiasis (Group 1), cholesterolosis (Group 2), and cholesterolosis and cholesterol polyp (Group 3). The groups were subjected to statistical analysis based on age, gender, cholesterol, triglyceride, low-density lipoprotein, high-density lipoprotein (HDL), alkaline phosphatase, gamma-glutamyl transferase (GGT), and C-reactive protein values.

Of the 227 cases included, 39 (17.2%) were male, and 188 (82.8%) were female. HDL value was significantly lower in men than in women (p = 0.00), while GGT (p = 0.00), aspartate aminotransferase (p = 0.01), and alanine aminotransferase (p = 0.00) values were significantly higher in men. No significant differences were detected in comparisons between pathological diagnostic groups (all p > 0.05).

No statistically significant findings were found regarding lipid profile and liver enzyme levels in cases of cholesterolosis, cholelithiasis, and cholesterol polyps. Although it is predicted that the HDL level being significantly lower in men than in women will increase the risk of polyp, no significant difference was detected between the pathological diagnosis groups in terms of gender. Studies containing larger case series are needed to reveal this relationship more clearly.