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Updated: May 24, 2026

A Behavioral Screen for Heat-Induced Seizures in Mouse Models of Epilepsy
06:58

A Behavioral Screen for Heat-Induced Seizures in Mouse Models of Epilepsy

Published on: July 12, 2021

Clinical and laboratory factors associated with recurrent and complex febrile seizures: a retrospective visit-based

Nicharee Mungklang1, Patrapon Saritshasombat2, Saranya Uthaima3

  • 1School of Pediatrics, Institute of Medicine, Suranaree University of Technology, Thailand.

Brain & Development
|May 22, 2026
PubMed

Insights

Younger age, family history, and lower hemoglobin predict febrile seizure (FS) recurrence. Poor growth increases complex FS risk, while SARS-CoV-2 infection may be protective. These factors aid in evaluating FS in children.

Area of Science:

  • Pediatrics
  • Neurology
  • Epidemiology

Background:

  • Patient-level risk factors for febrile seizures (FS) are known, but visit-based clinical characteristics require further study.
  • Understanding these factors is crucial for managing FS in pediatric populations.

Purpose of the Study:

  • To identify visit-based demographic, clinical, and laboratory factors associated with FS recurrence and complexity.
  • To analyze these factors in a pediatric cohort in Northeastern Thailand.

Main Methods:

  • Retrospective analysis of 117 FS-related visits (89 children, 6 months-5 years) from 2020-2024.
  • Comparison of profiles between first vs. recurrent episodes and simple FS (SFS) vs. complex FS (CFS).
  • Multivariable generalized estimating equations (GEE) used to identify associated factors, accounting for intra-patient correlation.

Main Results:

  • Younger age (OR 0.966), positive family history of FS (OR 3.384), and lower hemoglobin (Hb) (OR 0.550) were linked to recurrence.
  • Weight-for-age below the 3rd percentile was associated with increased odds of complex FS (CFS) (OR 15.004).
  • Concurrent SARS-CoV-2 infection showed an inverse association with CFS (OR 0.167).

Conclusions:

  • Febrile seizures exhibit clinical heterogeneity, with specific factors influencing recurrence and complexity.
  • Age, family history, Hb levels, growth status, and SARS-CoV-2 infection are key associated factors.
  • Findings support an informed approach to FS evaluation, optimizing acute care and reducing unnecessary investigations.
Abstract

Keywords:
Complex febrile seizureFebrile seizureRecurrenceRisk factorSARS-CoV-2Simple febrile seizureVisit-based analysis

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