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Published on: September 27, 2024
An international multidisciplinary consensus statement on laparoscopic liver biopsy.
Si-Yi Lei1, Yu Han2, Don C Rockey3
1MAFLD Research Center, Department of Hepatology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China; Cixi Biomedical Research Institute, Wenzhou Medical University, Wenzhou, China.
Laparoscopic liver biopsy is a method to collect liver tissue samples using a visual approach. It is used in complex or high-risk cases where traditional percutaneous biopsy may not be suitable. Clinical practices for this procedure vary globally due to the lack of standardized guidelines. To address this, a group of 45 international experts from multiple disciplines developed a consensus using a structured Delphi process. The statement covers when to use laparoscopic biopsy, how to prepare for it, the surgical steps, and how to manage complications. The authors suggest that this guidance may help standardize the procedure, improve safety, and support its appropriate use in complex cases. The consensus aims to promote better diagnostic outcomes and consistent clinical practice.
Area of Science:
- Hepatobiliary surgery
- Gastrointestinal surgery
- Diagnostic imaging in liver disease
Background:
Clinical practices for laparoscopic liver biopsy differ between institutions, partly due to the absence of global guidelines. It is known that percutaneous liver biopsy is commonly used, but it may not be suitable for all patients. Some cases involve high risk or anatomical complexity, making alternative methods necessary. Laparoscopic liver biopsy offers a visual approach to tissue sampling, which may improve diagnostic accuracy. However, its use is not yet standardized globally. This lack of consensus can lead to inconsistent outcomes and safety profiles. No prior work had resolved how to standardize the technique across disciplines. That uncertainty drove the need for a multidisciplinary consensus. This gap motivated the development of a unified framework for laparoscopic liver biopsy.
Purpose Of The Study:
This study aimed to establish international standards for laparoscopic liver biopsy. The goal was to address variability in clinical use and procedural safety. A group of experts from multiple disciplines collaborated to define best practices. They focused on scenarios where laparoscopic biopsy is most appropriate. The study also aimed to clarify how to manage complications and ensure quality control. It sought to support the use of this technique in complex or high-risk cases. The panel aimed to provide guidance for preoperative preparation and surgical steps. This effort aimed to facilitate the safe and effective use of laparoscopic liver biopsy worldwide.
Main Methods:
The panel included 45 experts from six continents across multiple disciplines. They used a modified Delphi process to reach agreement on key aspects of laparoscopic liver biopsy. Three rounds of consultation were conducted to refine the consensus. Topics covered clinical use, risk factors, and procedural steps. The process involved iterative discussion and voting to finalize recommendations. Each round aimed to reduce disagreement and align expert opinions. The final statement included guidance on preoperative, intraoperative, and postoperative care. The method ensured that all relevant clinical considerations were addressed.
Main Results:
The consensus statement outlines clinical scenarios where laparoscopic biopsy is preferred. It identifies high-risk cases that may benefit from this approach. The panel agreed on preoperative preparation steps to minimize complications. They provided detailed guidance on the surgical procedure itself. Postoperative management and discharge criteria were also standardized. The statement includes strategies for managing potential complications. It emphasizes the importance of quality control in tissue sampling. These findings aim to improve diagnostic accuracy and patient safety.
Conclusions:
The authors propose that this consensus promotes the safe and standardized use of laparoscopic liver biopsy. They suggest that it supports the management of complex and high-risk cases. The statement may help reduce variability in clinical practice across centers. The authors propose that it facilitates the appropriate implementation of this procedure. They suggest that the guidance improves diagnostic efficiency and procedural quality. The authors propose that it supports multidisciplinary collaboration in liver diagnostics. They suggest that the statement may serve as a reference for future clinical decisions. The authors propose that it enhances the rational clinical application of laparoscopic liver biopsy.
Frequently Asked Questions
The authors propose that the statement aims to standardize the use of laparoscopic liver biopsy for complex or high-risk cases.
A panel of 45 experts from six continents used a modified Delphi process over three rounds to reach agreement.
The statement includes guidance on clinical use, preoperative preparation, surgical steps, and complication management.
The authors suggest that it may be safer for high-risk patients or those with complex anatomy where percutaneous biopsy is not feasible.
The authors propose that the statement includes strategies for managing complications and discharge criteria to ensure patient safety.
The authors propose that it may reduce variability in laparoscopic liver biopsy use and improve diagnostic accuracy and safety.

