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Updated: May 24, 2026
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Drug-Induced Sleep Endoscopy (DISE) with Target Controlled Infusion (TCI) and Bispectral Analysis in Obstructive Sleep Apnea
Published on: December 6, 2016
Does Obstructive Sleep Apnea Affect Complications or Patient-Reported Outcomes Following Primary Total Knee
Hahn Kang1, Muhammad Hamza Ilyas1, Isaiah Freeman1
1Bioengineering Laboratory, Department of Orthopaedic Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
The Journal of Arthroplasty
|May 22, 2026
Summary
Obstructive sleep apnea (OSA) does not increase complications after total knee arthroplasty (TKA). Patients with OSA experience similar functional improvements and pain relief, despite lower initial scores.
Area of Science:
- Orthopedic Surgery
- Sleep Medicine
- Patient Outcomes Research
Background:
- Obstructive sleep apnea (OSA) affects over 10% of adults.
- Conflicting data exists on OSA's impact on total knee arthroplasty (TKA) outcomes.
- Few studies have analyzed patient-reported outcome measures (PROMs) in this context.
Purpose of the Study:
- To compare PROMs and postoperative complications after primary TKA in patients with and without OSA.
- To utilize a propensity-matched analysis for robust comparison.
- To investigate the influence of OSA on patient-perceived functional recovery and pain.
Main Methods:
- A propensity-matched analysis of 1,119 patients with OSA and 1,119 without OSA from a primary TKA database.
- Evaluation of 90-day medical and 1- and 2-year surgical complications.
- Assessment of PROMs including PROMIS Physical Function, PROMIS Global Health, and KOOS-PSF, analyzing absolute scores, delta scores, and MCID.
Main Results:
- No significant differences in medical or surgical complications between OSA and non-OSA cohorts.
- Patients with OSA reported lower absolute postoperative PROMs but similar delta scores and MCID response rates.
- Continuous positive airway pressure use in OSA patients correlated with similar PROM improvements.
Conclusions:
- Preoperative OSA is not associated with increased complications following primary TKA.
- Despite lower absolute scores, patients with OSA achieve comparable functional improvements and clinically meaningful benefits post-TKA.
- OSA status does not impede the patient-perceived success of TKA.
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