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Updated: May 24, 2026
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Biomolecular Imaging of Cellular Uptake of Nanoparticles using Multimodal Nonlinear Optical Microscopy
Published on: May 16, 2022
Exploring the interactions between nanoparticles and biological organisms using advanced imaging and omics
Chen Guo1, Yu Zhong1, Jie Lin2
1Fujian Provincial Key Laboratory of Tumor Biotherapy, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou 350014, China.
Acta Biomaterialia
|May 22, 2026
Summary
Understanding nanoparticle fate in vivo is key for drug delivery. This review explores how advanced imaging and multi-omics approaches can reveal nanoparticle bio-disposition and interactions within organisms.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Pharmacology
Background:
- Nanoparticle drug delivery shows limited clinical success due to poor understanding of in vivo behavior.
- The in vivo fate and bio-disposition of nanoparticles remain poorly characterized, hindering optimization.
- Current research often overlooks comprehensive nanoparticle-organism interactions.
Purpose of the Study:
- To review advances in nanoparticle imaging and omics technologies for studying in vivo fate.
- To synthesize research paradigms using multi-omics for nanocarrier-biological system interactions.
- To examine the application of multi-omics in nanoparticle optimization, target discovery, and bio-disposition characterization.
Main Methods:
- Review of recent literature on nanoparticle imaging technologies.
- Analysis of omics approaches applied to nanoparticle-biological system interactions.
- Synthesis of multi-omics study designs for investigating nanoparticle bio-disposition.
Main Results:
- Omics technologies offer insights into nanoparticle mechanisms of action, pharmacodynamics, and toxicology.
- Multi-omics approaches can elucidate the in vivo processing and bio-disposition of nanoparticles.
- Combining omics with imaging can provide a more complete picture of nanoparticle-organism interactions.
Conclusions:
- Omics technologies are crucial for understanding nanoparticle in vivo fate and improving drug delivery systems.
- Multi-omics approaches complement traditional imaging, advancing nanoparticle design and application.
- This review highlights a novel perspective using omics for studying nanoparticle bio-disposition and optimizing nanomedicines.
