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Updated: May 24, 2026

Basophil Activation Test for Allergy Diagnosis

Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

Bupropion-induced early-onset urticaria.

Vijay Kumar Saini¹, Akshaya B Raj², Sanyam Tyagi²

¹Psychiatry, All India Institute of Medical Sciences Jodhpur, Jodhpur, Rajasthan, India sainivk@aiimsjodhpur.edu.in.

BMJ Case Reports

|May 22, 2026

Summary

This summary is machine-generated.

Bupropion can cause early-onset urticaria and angioedema within days of starting treatment. Discontinuing bupropion (a norepinephrine-dopamine reuptake inhibitor) led to symptom resolution, indicating a probable drug reaction.

Keywords:

Depressive disorder Dermatology Psychiatry (drugs and medicines)Skin

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Area of Science:

Pharmacology
Dermatology
Clinical Medicine

Background:

Bupropion, a norepinephrine-dopamine reuptake inhibitor, is frequently prescribed for depression and smoking cessation.
While generally well-tolerated, bupropion can rarely cause hypersensitivity reactions.
Delayed-onset urticaria is an uncommon but documented adverse effect.

Purpose of the Study:

To report a case of early-onset urticaria and angioedema following bupropion initiation.
To emphasize the temporal relationship between bupropion use and cutaneous hypersensitivity.
To discuss clinical challenges in managing bupropion-induced hypersensitivity reactions.

Main Methods:

Case report detailing a patient's experience with bupropion.
Documentation of symptom onset, progression, and response to treatment.
Assessment of adverse drug reaction probability using the Naranjo scale.

Main Results:

The patient developed angioedema on day 4 and urticaria on day 5 of bupropion treatment.
Antihistamine therapy was ineffective; symptoms resolved within 7 days of discontinuing bupropion.
The Naranjo score of 7 indicated a probable association between bupropion and the hypersensitivity reaction.

Conclusions:

Early-onset cutaneous hypersensitivity reactions, including urticaria and angioedema, can occur with bupropion.
Clinical vigilance is necessary to recognize these uncommon adverse effects.
Prompt discontinuation of bupropion is crucial for symptom resolution.