Bupropion-induced early-onset urticaria.

Area of Science:

• Pharmacology
• Dermatology
• Clinical Medicine

Background:

• Bupropion, a norepinephrine-dopamine reuptake inhibitor, is frequently prescribed for depression and smoking cessation.
• While generally well-tolerated, bupropion can rarely cause hypersensitivity reactions.
• Delayed-onset urticaria is an uncommon but documented adverse effect.

Purpose of the Study:

• To report a case of early-onset urticaria and angioedema following bupropion initiation.
• To emphasize the temporal relationship between bupropion use and cutaneous hypersensitivity.
• To discuss clinical challenges in managing bupropion-induced hypersensitivity reactions.

Main Methods:

• Case report detailing a patient's experience with bupropion.
• Documentation of symptom onset, progression, and response to treatment.
• Assessment of adverse drug reaction probability using the Naranjo scale.

Main Results:

• The patient developed angioedema on day 4 and urticaria on day 5 of bupropion treatment.
• Antihistamine therapy was ineffective; symptoms resolved within 7 days of discontinuing bupropion.
• The Naranjo score of 7 indicated a probable association between bupropion and the hypersensitivity reaction.

Conclusions:

• Early-onset cutaneous hypersensitivity reactions, including urticaria and angioedema, can occur with bupropion.
• Clinical vigilance is necessary to recognize these uncommon adverse effects.
• Prompt discontinuation of bupropion is crucial for symptom resolution.