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Related Experiment Video

Updated: May 24, 2026

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
11:17

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Published on: August 30, 2018

Antibiotic Stewardship for the Intensivist.

Armani M Hawes1, Sara E Cosgrove1

  • 1Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Critical Care Clinics
|May 22, 2026
PubMed
Summary
This summary is machine-generated.

Intensive care units (ICUs) use the most antibiotics. Improving antibiotic stewardship in ICUs involves de-escalating or stopping antibiotics based on data and using shorter treatment durations to minimize exposure.

Keywords:
Antibiotic stewardshipCritical illnessDe-escalationDuration of therapy

Related Experiment Videos

Last Updated: May 24, 2026

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
11:17

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Published on: August 30, 2018

Area of Science:

  • Critical care medicine
  • Infectious diseases
  • Pharmacology

Background:

  • Intensive care units (ICUs) admit the most critically ill patients.
  • ICUs account for a significant portion of hospital antibiotic consumption.
  • Optimal and timely antibiotic therapy is crucial for critically ill patients.

Purpose of the Study:

  • To identify opportunities for improving antibiotic use in ICUs.
  • To promote antibiotic de-escalation and discontinuation strategies.
  • To reduce overall antibiotic exposure in critically ill patients.

Main Methods:

  • Reviewing antibiotic use patterns in the ICU.
  • Implementing antibiotic de-escalation based on clinical data and cultures.
  • Selecting shorter antibiotic durations guided by clinical trials.
  • Collaborating with hospital antibiotic stewardship programs.

Main Results:

  • Opportunities exist to optimize antibiotic prescribing in ICUs.
  • De-escalation or discontinuation of antibiotics can be guided by data.
  • Minimizing antibiotic exposure through shorter durations is beneficial.

Conclusions:

  • Antibiotic stewardship initiatives are vital for ICUs.
  • Tailoring antibiotic therapy based on patient data and evidence can improve outcomes.
  • Collaboration between ICUs and stewardship programs is essential for effective antibiotic use.