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Related Concept Videos

Genomics02:02

Genomics

Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
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Statistical software is pivotal in data analysis and clinical trials by providing tools to analyze data, draw conclusions, and make predictions. These software packages range from simple data management applications to complex analytical platforms, supporting various statistical tests, models, and simulation techniques. Their significance lies in their ability to handle vast amounts of data with precision and efficiency, enabling researchers to validate hypotheses, identify trends, and make...
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Next-generation Sequencing

The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
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DNA Microarrays02:34

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Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...

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Related Experiment Video

Updated: May 24, 2026

Analyzing Tumor Gene Expression Factors with the CorExplorer Web Portal
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Published on: October 11, 2019

Development of K-CORE: a web-based platform for integrated clinico-genomic analysis.

Juyeon Hwang1, Jae Woo Ahn1, Jae Wook Lee2

  • 1National Cancer Control Institute, National Cancer Center, Goyang, South Korea.

Life Science Alliance
|May 22, 2026
PubMed
Summary

The Korea Cancer Omics Research (K-CORE) portal integrates multi-omics and clinical data for precision oncology. This user-friendly platform supports data analysis, advancing cancer research and treatment strategies.

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Last Updated: May 24, 2026

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Area of Science:

  • Bioinformatics
  • Genomics
  • Cancer Research

Background:

  • Integrating multi-omics and clinical data is crucial for precision oncology.
  • Existing platforms often lack support for user-uploaded data and integrated analysis.

Purpose of the Study:

  • To develop the Korea Cancer Omics Research (K-CORE) portal.
  • To create a user-friendly platform for integrating and analyzing multi-omics and clinical data.

Main Methods:

  • Developed the K-CORE portal supporting various omics levels and analytical tools.
  • Validated K-CORE using synthetic datasets mirroring real-world distributions.
  • Compared K-CORE analytical results with established R packages (maftools, edgeR).

Main Results:

  • K-CORE successfully integrates multi-omics and clinical data.
  • The platform demonstrated utility and reproducibility through synthetic data validation.
  • Analytical outputs from K-CORE were comparable to existing R packages.

Conclusions:

  • K-CORE provides a practical and intuitive solution for multidomain data integration in precision oncology.
  • The platform supports advancements in cancer treatment and research.
  • Continuous maintenance and user feedback are vital for future improvements.