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Cutaneous Hemangioma With Epithelioid Features Harboring a TPM4::ALK Fusion
Donn LaTour1, Norman L Lehman2, Martin P Fernandez2
1Department of Dermatology, Baylor Scott & White Health, Temple, Texas, USA.
Researchers identified a rare TPM4::ALK gene fusion in a benign epithelioid hemangioma, a vascular neoplasm. This finding highlights ALK as a potential driver in these fusion-driven tumors.
Area of Science:
- Oncology
- Genetics
- Dermatopathology
Background:
- Vascular neoplasms are diverse, with gene fusions increasingly defining their classification.
- Epithelioid hemangiomas are benign vascular tumors often characterized by FOS gene rearrangements.
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