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Biventricular Assessment of Cardiac Function and Pressure-Volume Loops by Closed-Chest Catheterization in Mice

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Periodontitis and its association with left ventricular geometry and function: A cross-sectional study.

Maja Trost¹, Till Ittermann², Birte Holtfreter¹

¹Department of Restorative Dentistry, Periodontology and Endodontology, University Medicine Greifswald, Greifswald, Germany.

Journal of Periodontology

|May 22, 2026

Summary

Periodontitis is associated with cardiac remodeling, including increased left ventricular (LV) volume and mass. Integrating dental health into cardiovascular risk assessment may be beneficial.

Keywords:

cardiac remodeling cardiovascular diseases left ventricular function left ventricular geometry periodontitis

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Area of Science:

Cardiology
Periodontology
Public Health

Background:

Cardiovascular disease (CVD) is a leading cause of mortality.
Periodontal disease is prevalent and linked to systemic inflammation.
Early detection of cardiac changes is crucial for CVD risk stratification.

Purpose of the Study:

To investigate the association between periodontal status and left ventricular (LV) geometry and function.
To determine if periodontal disease markers correlate with cardiac remodeling.
To explore the potential of periodontal assessment in cardiovascular risk evaluation.

Main Methods:

Utilized data from two population-based cohorts (SHIP-START-2 and SHIP-TREND-0).
Assessed periodontal status via bleeding on probing (BOP), probing depth (PD), clinical attachment loss (CAL), and missing teeth.
Classified periodontitis using a modified 2018 framework and evaluated LV geometry/function via echocardiography.

Main Results:

Positive associations found between PD, CAL, missing teeth, and increased LV volumes and mass.
Periodontitis stages correlated with higher LV volumes and mass (p < 0.05).
Stage IV periodontitis was linked to reduced ejection fraction, though other functional markers were not significant.

Conclusions:

Periodontitis markers are associated with cardiac remodeling, specifically increased LV volume and mass.
Findings suggest integrating periodontal assessment into cardiovascular risk evaluation.
Clinical relevance requires further investigation due to small effect sizes.