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Updated: May 24, 2026

Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells
10:06

Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells

Published on: April 26, 2017

RNA splicing in cancer cell death regulation: shedding light on the molecular mechanisms and potential clinical

Minghui Song1, Yaru Wang1, Haiyun Zhang1

  • 1School of Pharmacy and Department of Hepatology, the Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, Hangzhou, PR China.

Cell Death & Disease
|May 22, 2026
PubMed

Insights

Alternative splicing (AS) regulates cell death, impacting cancer development. Targeting AS-mediated regulatory cell death (RCD) offers potential new cancer therapies.

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Oncology

Background:

  • Alternative splicing (AS) generates protein diversity from a single gene via the spliceosome.
  • Dysregulation of regulatory cell death (RCD) pathways like apoptosis and ferroptosis is linked to cancer.
  • Aberrant AS events involving spliceosome components and splicing factors can influence RCD and contribute to tumorigenesis.

Purpose of the Study:

  • To review the role of alternative splicing in tumor regulatory cell death.
  • To elucidate the mechanisms by which AS modulates various RCD modes.
  • To summarize potential clinical applications of targeting AS-RCD pathways in cancer therapy.

Main Methods:

  • Literature review focusing on alternative splicing and regulatory cell death.
  • Analysis of molecular mechanisms linking AS to different RCD pathways.
  • Synthesis of current research on clinical applications of AS-RCD targeting.

Main Results:

  • AS plays a significant role in modulating diverse RCD pathways.
  • Specific AS events and splicing factors are implicated in cancer progression via RCD.
  • Targeting AS-RCD interactions presents a promising therapeutic strategy for cancer.

Conclusions:

  • Alternative splicing is a key regulator of tumor cell death pathways.
  • Understanding AS-mediated RCD offers mechanistic insights into tumorigenesis.
  • Targeting AS-RCD axes holds potential for novel cancer treatments.

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