Related Experiment Video
Updated: May 24, 2026
07:03
Evaluation of Hemisphere Lateralization with Bilateral Local Field Potential Recording in Secondary Motor Cortex of Mice
Published on: July 31, 2019
Stronger right-hemispheric involvement in language processing is associated with greater functional connectivity
Victor Karpychev1,2, Svetlana Malyutina3, Olga Dragoy3,4
1Department of Neurology, School of Medicine, Emory University, 12 Executive Park Dr NE, Atlanta, GA, 30329, USA. karpuchevvictor@gmail.com.
Brain Structure & Function
|May 22, 2026
Summary
Reduced left-hemispheric language lateralization in adults doesn't link to other networks. Stronger right-hemisphere language processing correlates with increased left-lateralized language network connectivity to the cingulo-opercular network (CON).
Area of Science:
- Neuroscience
- Cognitive Neuroscience
- Psycholinguistics
Background:
- Language processing is primarily left-lateralized in the language-related network (LRN).
- Right-hemispheric regions can contribute to language, reducing left-hemispheric lateralization.
- The relationship between reduced lateralization and other network interactions during language tasks is not well understood.
Purpose of the Study:
- To investigate how individual differences in left-hemispheric language lateralization relate to non-language network activation.
- To examine the connectivity between the LRN and other networks based on language lateralization.
- To explore the neural underpinnings of varying degrees of language lateralization.
Main Methods:
- Task-based functional magnetic resonance imaging (fMRI) data from 50 healthy adults completing sentence-completion tasks.
- Independent Component Analysis (ICA) to identify distinct brain networks.
- Analysis of LRN connectivity to other networks in relation to language lateralization.
Main Results:
- Identified both left- and right-lateralized LRNs.
- The salience network co-activated with both LRNs irrespective of individual lateralization.
- Weaker lateralization was not linked to domain-general network activation or LRN connectivity.
- Stronger right-hemispheric involvement showed greater LRN connectivity to the cingulo-opercular network (CON).
Conclusions:
- Individual language lateralization is associated with specific network interactions, particularly with the CON.
- Increased right-hemispheric involvement in language processing may involve enhanced cognitive control via the CON.
- Findings suggest a more complex interplay of brain networks in language processing than previously assumed.
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