Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...

Modified-Release Drug Delivery Systems: Stimuli-Activated

Modified-Release Drug Delivery Systems: Stimuli-Activated

Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also called...

Modified-Release Drug Delivery Systems: Site-Targeted

Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.

Defense Against Bacterial Pathogens

Defense Against Bacterial Pathogens

The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...

Modified-Release Drug Delivery Systems: Classification

Modified-Release Drug Delivery Systems: Classification

Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...

Clinical Significance of Antibiotic Resistance

Clinical Significance of Antibiotic Resistance

Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A general and green approach of pH-sensitive ZIF-67 for encapsulating active substances.

Smart molecules : open access·2026

Same author

Ultrasound-Responsive Calcium Copper Phosphate Nanomaterials Induce Tumor Cell Death via the Synergistic Release of Copper and Calcium.

International journal of molecular sciences·2026

Same author

Self-Assembly of a Rosin-Derived Glycosylated Surfactant into Chiral Wormlike Micelles with Unusual Viscoelasticity.

Journal of agricultural and food chemistry·2026

Same author

Oil-in-dispersion emulsions stabilized by electrostatic repulsions between surfactant and tea polyphenol nanoparticles.

Chemical communications (Cambridge, England)·2026

Same author

Current advancements in the investigation of mitochondria-targeting organic sensitizers in cancer immunotherapy.

Biomaterials science·2025

Same author

Advances in Prostate Cancer Biomarkers and Probes.

Cyborg and bionic systems (Washington, D.C.)·2025

Search research articles

Related Experiment Video

Updated: May 24, 2026

High-throughput Identification of Bacteria Repellent Polymers for Medical Devices

High-throughput Identification of Bacteria Repellent Polymers for Medical Devices

Published on: November 5, 2016

Bacterial Microenvironment-Responsive Polymeric Carriers for Antibacterial Agent Delivery.

Ming Liu¹, Lizhuang Zhong¹, Tingting Yan¹

¹Faculty of Flavour Fragrance and Cosmetics, Shanghai Institute of Technology, Shanghai 201418, P. R. China.

Biomacromolecules

|May 22, 2026

Summary

Smart polymeric carriers that respond to the bacterial microenvironment offer precise targeting and controlled release of antibacterial agents. This approach enhances drug efficacy and combats rising antimicrobial resistance, paving the way for advanced infection treatments.

More Related Videos

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles

Published on: August 28, 2015

Production of Near-Infrared Sensitive, Core-Shell Vaccine Delivery Platform

Production of Near-Infrared Sensitive, Core-Shell Vaccine Delivery Platform

Published on: October 20, 2020

Related Experiment Videos

Last Updated: May 24, 2026

High-throughput Identification of Bacteria Repellent Polymers for Medical Devices

High-throughput Identification of Bacteria Repellent Polymers for Medical Devices

Published on: November 5, 2016

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles

Published on: August 28, 2015

Production of Near-Infrared Sensitive, Core-Shell Vaccine Delivery Platform

Production of Near-Infrared Sensitive, Core-Shell Vaccine Delivery Platform

Published on: October 20, 2020

Area of Science:

Biomaterials Science
Drug Delivery
Infectious Diseases

Background:

Rising antimicrobial resistance and drug inactivation necessitate novel antibacterial strategies.
Polymeric delivery systems improve antibacterial agent stability and reduce toxicity.
Conventional carriers lack precise targeting and controlled release capabilities.

Purpose of the Study:

To review recent advancements in bacterial microenvironment-responsive polymeric carriers for antibacterial delivery.
To elucidate response mechanisms, carrier types, and delivery modalities.
To highlight challenges, opportunities, and design principles for next-generation systems.

Main Methods:

Comprehensive literature review of bacterial microenvironment-responsive polymers.
Analysis of pH, enzyme, and redox-responsive mechanisms.
Evaluation of various polymeric carrier types and their applications.

Main Results:

Responsive polymers enable precise targeting and on-demand release of antibacterial agents.
These systems enhance stability, circulation time, and reduce cytotoxicity.
Key response mechanisms and applicable scenarios were identified.

Conclusions:

Bacterial microenvironment-responsive polymers represent a promising platform for advanced antibacterial drug delivery.
Further research into material design and responsive schemes is crucial for clinical translation.
These smart systems offer a theoretical foundation for combating bacterial infections effectively.