Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Sputum Studies II: Culture and Sensitivity01:20

Sputum Studies II: Culture and Sensitivity

Description
Sputum culture and sensitivity is a medical procedure used to diagnose bacterial infections in the respiratory tract and select the most appropriate antibiotics for treatment. This process involves analyzing sputum samples of thick and opaque secretions produced in the lungs and airways. These samples are collected from patients and then sent to the laboratory for analysis.
The test can identify various pathogens responsible for respiratory infections, including Streptococcus,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

What Is the Role of Uvulopalatopharyngoplasty in Contemporary Sleep Surgery?

The Laryngoscope·2026
Same author

Barriers to Care for Obstructive Sleep Apnea: Primary Care Perspectives at a Safety Net Hospital.

Laryngoscope investigative otolaryngology·2026
Same author

Location Matters for Proximal Hilar Submandibular Stone Removal: Position Relative to the Mylohyoid.

The Laryngoscope·2026
Same author

Insomnia as a Clinical Predictor of Hypoglossal Nerve Stimulation Settings and Treatment Success.

The Laryngoscope·2026
Same author

Identifying Stimulation Lead Malfunction After Hypoglossal Nerve Stimulation Implantion.

The Laryngoscope·2026
Same author

Association Between Biologic Therapy and Reduced Acute Rhinosinusitis Episodes: A Retrospective Database Study.

Laryngoscope investigative otolaryngology·2026

Related Experiment Video

Updated: May 24, 2026

Sublingual Immunotherapy as an Alternative to Induce Protection Against Acute Respiratory Infections
16:56

Sublingual Immunotherapy as an Alternative to Induce Protection Against Acute Respiratory Infections

Published on: August 30, 2014

Longitudinal SNOT-22 Symptom Changes With Sublingual Immunotherapy (SLIT).

Wynne Zheng1, Jolie L Chang1, Anna Butrymowicz1

  • 1Department of Otolaryngology-Head and Neck Surgery, University of California San Francisco, San Francisco, California, USA.

The Laryngoscope
|May 23, 2026
PubMed
Summary
This summary is machine-generated.

Sublingual immunotherapy (SLIT) offers significant allergic rhinitis (AR) symptom relief within six months, improving nasal congestion, sleep, and daily function. These benefits persist for at least one year, reducing overall symptom burden.

Keywords:
SNOT‐22allergic rhinitispatient‐reported outcomessublingual immunotherapy

More Related Videos

Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis
03:40

Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis

Published on: December 20, 2024

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber
08:47

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber

Published on: March 3, 2023

Related Experiment Videos

Last Updated: May 24, 2026

Sublingual Immunotherapy as an Alternative to Induce Protection Against Acute Respiratory Infections
16:56

Sublingual Immunotherapy as an Alternative to Induce Protection Against Acute Respiratory Infections

Published on: August 30, 2014

Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis
03:40

Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis

Published on: December 20, 2024

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber
08:47

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber

Published on: March 3, 2023

Area of Science:

  • Allergy and Immunology
  • Otolaryngology
  • Sleep Medicine

Background:

  • Allergic rhinitis (AR) significantly impacts quality of life, with persistent symptoms like nasal congestion and rhinorrhea despite standard treatments.
  • Sublingual immunotherapy (SLIT) is an alternative treatment for AR, aiming to reduce symptom burden and medication reliance.

Purpose of the Study:

  • To evaluate the time to clinical benefit and the magnitude of the first-year benefit in adult patients with AR initiating SLIT.
  • To assess symptom improvement using validated patient-reported outcome measures.

Main Methods:

  • Adult AR patients undergoing SLIT were enrolled.
  • Sinonasal Outcome Test-22 (SNOT-22) and Rhinitis Control Assessment Test (RCAT) scores were collected at baseline and at 1-6 and 6-12 months post-initiation.
  • Statistical analysis, including repeated measures ANOVA and minimal clinically important difference (MCID) thresholds, was employed.

Main Results:

  • Significant reductions in total SNOT-22 scores were observed at 1-6 months (-35%) and 6-12 months (-36%) (p < 0.01).
  • Improvements were noted in nasal, sleep, and function SNOT-22 subscores, with 54.3% of patients achieving MCID for total SNOT-22 within 6 months.
  • RCAT scores also showed significant improvement, and the proportion of patients with normal SNOT-22 scores increased from 4.7% to 24.1%.

Conclusions:

  • SLIT demonstrates efficacy in improving allergic rhinitis symptoms within the first six months of therapy.
  • Symptom improvements, particularly in nasal, sleep, and functional domains, are sustained up to 12 months.
  • Findings support SLIT as an effective treatment for early and persistent symptom alleviation in AR.