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Updated: May 24, 2026

The ITS2 Database
Published on: March 12, 2012
Connecting Terminology Servers with a Metadata Repository
Larie Borelle Siabou1,2, Abishaa Vengadeswaran1, Dupleix Achille Takoulegha2
1Institute of Medical Informatics, Goethe University Frankfurt, University Hospital Frankfurt, Germany.
None:
The increasing complexity of medical data requires standardised terminologies and metadata for interoperable processing. Terminology servers provide controlled vocabularies, while metadata repositories structure data elements according to standards such as ISO 11179 and 21526. The aim of this work was to develop and prototype an integration concept that connects both systems to improve semantic and syntactic interoperability. Requirements derived from an ongoing PRISMA-guided systematic review were incorporated into the prototype implementation of two key features within the DataElementHub (DEHub): (1) concept association that link data elements to terminology codes, and (2) defined value domain that refer to external ValueSets. Validation using annotated datasets confirmed the feasibility and highlighted future needs, such as harmonising terminology structures, improving version management, and resolving licensing issues. Overall, the integration of terminology servers into metadata repositories strengthens interoperability and supports the FAIR principles.
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