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Related Experiment Video

Updated: May 24, 2026

Analyzing Tumor Gene Expression Factors with the CorExplorer Web Portal

Analyzing Tumor Gene Expression Factors with the CorExplorer Web Portal

Published on: October 11, 2019

Support for Molecular Tumor Board Presentations in cBioPortal.

Dominik Boehm^1,2, Marco Schindler, Cosima Strantz³

¹Uniklinikum Erlangen, Medical Center for Information and Communication Technology, Erlangen, Germany.

Studies in Health Technology and Informatics

|May 23, 2026

Summary

Molecular tumor boards (MTBs) streamline precision cancer treatment by integrating genomic data. A new MTB-cBioPortal extension simplifies case preparation and presentation, improving workflow efficiency.

Keywords:

Case Presentation MTB-cBioPortal Molecular Tumor Board Oncology Personalized Medicine Therapy Recommendation cBioPortal

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Area of Science:

Oncology
Bioinformatics
Medical Informatics

Background:

Molecular tumor boards (MTBs) are crucial for personalized precision oncology.
MTB case preparation is resource-intensive, hindering efficient treatment decision-making.
Existing platforms lack integrated tools for digital slide and report management within MTB workflows.

Purpose of the Study:

To develop and evaluate an extension for the MTB-cBioPortal to streamline MTB case preparation and presentation.
To enhance the integration of clinical, genomic, and imaging data for oncology treatment planning.
To improve the usability and efficiency of molecular tumor board discussions.

Main Methods:

Collaborative development of a MTB-cBioPortal extension with clinicians.
Analysis of existing MTB case presentations to define functional requirements.
Integration of clinical/genomic data, visualization tools, and local file uploads (pathology slides, reports).
Storage of presentations as FHIR resources.
Usability evaluation using the System Usability Scale with a multidisciplinary MTB team.

Main Results:

The MTB-cBioPortal extension facilitates digital slide set preparation and presentation within the platform.
The tool integrates mutation overviews, patient timelines, and local image/report uploads.
Presentations are stored as FHIR resources.
Usability testing yielded excellent results (96th percentile), indicating high user satisfaction.

Conclusions:

The developed MTB-cBioPortal extension significantly enhances the efficiency of preparing and presenting cases for molecular tumor boards.
The tool has strong potential for integration into routine MTB workflows, supporting personalized precision medicine.
Improved data integration and presentation capabilities can optimize treatment decisions in oncology.