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Updated: May 24, 2026

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
Published on: June 13, 2025
Garbage In, Garbage Out: Context Engineering for Generating Multiple-Choice Questions for Medical Education Using
Michael Grössler1, Layla Tabea Riemann1
1Institute for Applied Medical Informatics, University Medical Center Hamburg-Eppendorf (UKE), Germany.
Generating automated medical education questions is hard. A new platform using a Knowledge Graph (KG) significantly improved the quality of multiple-choice questions (MCQs) compared to unstructured text.
Area of Science:
- Medical Education Technology
- Artificial Intelligence in Education
- Knowledge Representation
Background:
- Automated generation of high-quality multiple-choice questions (MCQs) for medical education is a persistent challenge.
- Existing methods often struggle with contextual accuracy and relevance.
Purpose of the Study:
- To develop and evaluate KiMED, a novel platform for automated MCQ generation in German.
- To enhance MCQ quality by integrating Knowledge Graph (KG)-assisted retrieval with large language models (LLMs).
Main Methods:
- Biochemistry course materials were processed to construct a KG, extracting entities, properties, and relationships.
- A multi-agent system utilized the KG to generate MCQs, including question stems, correct answers (keys), and incorrect answers (distractors).
- LLM-based generation was enhanced by KG-assisted retrieval for precise, contextually relevant information.
Main Results:
- The constructed KG accurately represented 87% of entities and 82% of relationships from the source material.
- MCQs generated using the KG approach achieved a 45% usability rate among experts.
- MCQs generated from unstructured text showed a significantly lower usability rate of 23%.
Conclusions:
- Structured context, particularly through KGs, substantially improves the quality of automatically generated MCQs.
- Further optimization of context, agent workflows, and post-processing is necessary for reliable automated question generation.
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