The correlation between height and assay parameters in children with short stature

It is known that growth hormone plays a major role in children's height. This research was conducted to explore the connection between children's height and other parameters for potential diagnostic markers in cases of short stature. Information was gathered from children diagnosed with short stature from our hospital, including fundamental data and assay findings, and was evaluated for the correlation between height and assay findings. The correlation between height and assay findings was evaluated using the Pearson correlation coefficient test. A total of 2396 children were included, with 61.4% being boys, who exhibited a higher prevalence across most age groups. The findings revealed moderate positive correlations between height and iron, hemoglobin, as well as a weak correlation with zinc (iron, r = 0.48, hemoglobin, r = 0.52, zinc, r = 0.29, P < .0001, respectively). Additionally, a moderate negative correlation was observed between height and 25-hydroxyvitamin D (r = -0.37, P < .0001). Height showed highly positive correlations with insulin-like growth factor-1 (r = 0.67, P < .0001) and insulin-like growth factor binding protein 3 levels (r = 0.66, P < .0001), and moderate positive associations with sex hormones (follicle-stimulating hormone: r = 0.43, luteinizing hormone: r = 0.42; testosterone: r = 0.5, P < .0001, respectively). Furthermore, a moderate positive correlation was found between height and glucose (r = 0.41, P < .0001), while no significant correlation was observed between height and lipid metabolism parameters. In summary, short stature is a prevalent issue in our country. The research emphasized the correlation of height with insulin-like growth factor-1, insulin-like growth factor binding protein 3, and other parameters, and a negligible correlation with lipid metabolism parameters. These findings can serve as valuable parameters for parents to seek medical attention for children exhibiting abnormal results.