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Association between cardiometabolic index and mortality risk in patients with depression: A comprehensive analysis

Yixuan Xie1, Jiawang Jin, Ting Zhou

  • 1Department of Public Health and Health Management, Gannan Medical University, Ganzhou, China.

Medicine
|May 23, 2026
PubMed

Insights

This study explored the cardiometabolic index (CMI) in adults with depression. Findings suggest CMI may help identify individuals at higher risk of mortality, aiding preventive strategies.

Area of Science:

  • Cardiology
  • Psychiatry
  • Epidemiology

Background:

  • Depression is linked to higher rates of cardiometabolic diseases and mortality.
  • The prognostic value of integrated biomarkers for mortality risk in depressed populations is not well understood, especially across diverse ethnicities.
  • The cardiometabolic index (CMI), a composite measure of central obesity and dyslipidemia, shows predictive utility in general populations but its role in depression is unknown.

Purpose of the Study:

  • To investigate and validate the association between the cardiometabolic index (CMI) and mortality risk in adults diagnosed with depression.
  • To assess CMI's utility as a prognostic tool for all-cause and cardiovascular mortality in a bi-national depressed population.
  • To determine if CMI can serve as a simple, cost-effective biomarker for identifying high-risk individuals with depression.

Main Methods:

  • Utilized data from two large, nationally representative cohorts: the US National Health and Nutrition Examination Survey and the China Health and Retirement Longitudinal Study.
  • Calculated CMI using waist-to-height ratio multiplied by the triglyceride/high-density lipoprotein-cholesterol ratio.
  • Employed Cox proportional hazards models to analyze the association between CMI and mortality, adjusting for potential confounders.

Main Results:

  • The study is designed to examine the association between CMI and mortality in adults with depression.
  • Results will indicate whether CMI is a significant predictor of all-cause and cardiovascular mortality in this population.
  • The bi-national analysis aims to provide robust evidence on CMI's prognostic value across different ethnicities.

Conclusions:

  • The study will evaluate the cardiometabolic index (CMI) as a prognostic tool for mortality risk in adults with depression.
  • Confirmation of CMI's utility could establish it as a valuable, cost-effective biomarker for risk stratification in depression.
  • Findings may facilitate targeted preventive strategies and improve clinical outcomes for individuals with depression and cardiometabolic risk factors.

Keywords:
cardiometabolic indexcohort studycross-cultural studydepressionmortalityprognosis

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